The concept of aerosol originated from Lynde's proposal in 1862 to prepare pressurized packaging with a saturated solution of gas. It was not until 1926 that Erik Rotheim, a Norwegian chemical engineer, used a liquefied gas system to prepare the original form of the modern aerosol.
In 1943, Goodhue prepared a portable insecticidal aerosol using dichlorodifluoromethane (trade name F12) as a projectile. This was probably the most significant practical development in the development of aerosol. Insecticidal aerosol was introduced in 1947, requiring very thick and heavy pressure tanks. With the successful development of low pressure projectile and low pressure vessel, the cost of aerosol has been reduced and developed rapidly. In the 1950s aerosol was used for skin diseases, wounds, burns and local infections, and in 1955 it was used for respiratory administration. In recent years, research in this field has become more and more active, and there are more and more products, including topical treatment drugs, antibiotics, disease-resistant herbs and so on. In addition, in recent years, more and more new technologies have been applied in aerosol. Firstly, the improvement of the drug delivery system itself, such as the new inhalation drug delivery device, has made the application of aerosol more and more convenient and more acceptable to patients. Secondly, new preparation technologies, such as the application of liposomes, precursor drugs and polymer carriers, can prolong the residence time of drugs in the lungs and play a role in slow release.
The dosage forms similar to aerosol include aerosol and powder aerosol. This chapter mainly introduces aerosol. The 2000 edition of the Chinese Pharmacopoeia contained 6 kinds of aerosol, and the 27th edition of the United States Pharmacopoeia contained 20 kinds of aerosol and 6 kinds of projectile.
Post time: Jan-17-2023